Accurately measuring and quantifying biomarkers in relevant matrices informs numerous aspects of clinical drug development. Biomarker assays can match patients to appropriate therapies and demonstrate a candidate drugs safety and efficacy, thus illuminating its potential for clinical and commercial success. Q2 Solutions offers a wide range of tailored and integrated liquid chromatography mass spectrometry services to support biomarker testing and quantitation, including LC/MS bioanalysis, LC/MS/MS analysis, hybrid LC-MS assays, small molecule LC/MS, and large molecule bioanalysis.
Formed in 2008, the LC-MS biologics team at Q2 Solutions is one of the few bioanalytical laboratories successfully employing both triple quadrupole and high-resolution mass spectrometry (HRMS) for biological analyte LC-MS quantitation. We lead the regulated bioanalysis CRO industry in HRMS capacity with 10 validated Quadrupole- Exactive (QE) orbitrap instruments. Extensive nano-LC capabilities together with a highly automated bead-based immunoprecipitation extraction process delivers unparalleled sensitivity and proven reproducibility. These advanced technologies and our depth of experience combine with a collaborative approach to solve your large molecule bioanalytical challenge.
Q2 Solutions helps customers evaluate in vitro properties and in vivo plasma/tissue exposures to optimize ADME properties for potential drug candidates and assess risk associated with metabolism and drug-drug interactions (DDI).
Q2 Solutions offers a full range of services for the development or technical transfer and validation of custom- designed assays and application to study sample testing for PK concentration, immunogenicity and biomarker testing. Ligand binding assays (LBA), typically in the format of immunoassays, are the standard for bioanalytical testing of large molecule drugs. Formats can include use of target, anti-idiotypic antibodies, anti-conjugate, enrichment approaches, and competitive assays depending on drug design and characteristics of the drug and reagents. Platforms including chromogenic ELISA, chemiluminescence, fluorescence and electrochemiluminescence that provide the standard basis for macromolecule drug testing.
Additional services include critical reagent conjugation and characterization, immunogenicity cut point statistical reports.
Specifica, a Q2 Solutions company, is applying its proven platform for antibody discovery to generate recombinant monoclonal antibody reagents. Our in vitro display approach eliminates the need for...
ImmunXperts, a Q2 Solutions company, provides functional insights into immune-mediated adverse events. We provide in silico and in vitro methods, using T-cell activation and proliferation as a...
If you’re looking for solutions to analytical challenges, you’ve come to the right place. Our highly trained scientists partner with you to provide a well-planned strategy, no matter where you are in...